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Generic bupropion 75 mg and buproprion 15 mg) or placebo. The primary endpoint Tadalafil dosage liquid was a composite measure for change from baseline in the Montgomery-Asberg Depression Rating Scale (MADRS) score ≥10, measured at the first visit.
RESULTS:
Patients with MDD rated their symptoms positively on the MADRS, as did placebo-treated patients. Patients receiving bupropion had significantly higher mean scores (11.1 [SD, 1.5]; P <.05) as compared with the placebo-treated patients (6.0 [SD, 2.4]; P =.01). At least 1 adverse event (n = 21) occurred less frequently (n = 27) in patients receiving either dose of bupropion than in those receiving placebo, even after adjusting for baseline values (3.3 [SD, 1.7]; P <.05). However, those receiving bupropion had 1.2-fold higher scores for total (P =.02), subscale.01), and MADRS scores (P <.001).
CONCLUSIONS:
Both bupropion and buproprion have similar effects on symptom severity and improvement, but the magnitude of benefit is small. Because the benefits of bupropion were only modestly additive with those of buproprion, we recommend bupropion as an alternative treatment for MDD and recommend continuation of bupropion therapy at the maintenance dose.
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