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Achat metformine 500 mg/day vs. placebo 12 months Trial phase III Open label, single-arm clinical trial No patients involved in the study (12). 88. Al-Hasnawi S, al-Wafi R, al-Sagallawy K, et al. Metformin 500mg $34.88 - $0.39 Per pill Efficacy of metformin vs. lovastatin in the acute stage of heart failure. The Arab Cardiovasc Intervention Project: a randomised, multinational, blinded, multicenter, double-blind trial. Lancet. 1993 Dec 30;343(8701):822-7. Open label, single-arm clinical trial No patients involved in the study No subjects randomized (12). 89. Boussina J, Fournier S, Al-Taleeb A, et al. Metformin for treatment of hypertension: systematic review evaluating its efficacy in hypertensive populations. Circulation. 2012 Apr 11. 90. Barbalich W, Steg PG. Effect of metformin on weight and obesity: what is the evidence? Diabetologia. 1990. 37(4): 511-20. Open label, non-randomized, non-controlled clinical trial No subjects involved in the study (13). 1991. Zorion A, Bohn J, Eitel JJ, et al. Effect of metformin on body weight and serum lipids. Metabolism. 1994. 48(3): 703-7. Open label, non-randomized, non-controlled clinical trial No subjects involved in the study No subjects randomized (14). 1992. Barbalich W, Sattin A, Bischoff R, et al. Metformin in patients with morbid obesity: a preliminary report. American Journal of Clinical Nutrition. 1996 May;67(5):764-7. Open label, non-randomized, non-controlled clinical trial No subjects involved in the study (13). 93. Reiser-Baumann J, Dominguez Z, Ritz E, et al. Metformin in obese patients with type 2 diabetes mellitus: a randomized double blind study. Diabetes Care. 1997 Aug;18(8):1335-42. Open label, randomized controlled clinical trial No subjects involved in the study (13). 94. Reiser-Baumann J, Dominguez Z, Ritz E, et al. Metformin in obese patients with type 2 diabetes mellitus: a randomized double blind study: pilot report (Abstract). Diabetes Care. 1999 Jul 22;23(7):1093-7. Open label, randomized controlled clinical trial No subjects involved in the study No subjects randomized (14). 95. Reiser-Baumann J, Vyhne M, Schäfer F, et al. Intravenous Metformin versus oral therapy in resistant, obese patients with type 2 diabetes. Diabetes Care. 1999;23(4):1160-6. Open label, randomized controlled clinical trial No subjects involved in the study No subjects randomized (14). 96. Béchault C, Reiser-Baumann J, Vyhne M, et al. Efficacy of Metformin in morbidly obese patients with type 2 diabetes mellitus: a randomized double blind placebo controlled trial. Diabetes Care. 2001 Oct;24(10):1313-8. Open label, randomized controlled clinical trial No subjects involved in the study No subjects randomized. 97. Zorion A, Barbalich J, Désastre E, et al.