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Finasteride drug group and two placebo groups. Overall, patients in the treatment groups showed less depression symptoms and greater improvement than patients in the control groups. Clinical Study Findings The study has been under way since November 2013 where all subjects received an average of nine months treatment, with the placebo group having less than 6 months. The drug treatment group improved at a faster rate compared to the initial in placebo group, on average, while the control group continued to decline. The study noted that in addition to the improvement depressive symptoms observed by both the study and statistical analysis of the data, number patients who entered the study with clinically significant depression at the outset was significantly less than the number of patients in control groups who entered the study with such symptoms. The study also noted that number of patients who entered the study with comorbid alcohol and substance use disorder was also significantly less than the number of patients in control groups. The study concluded that "Clinical outcome data demonstrate there may be important clinical benefits of sertraline treatment as compared with placebo in a subgroup of patients with MDD." Sertraline is a selective serotonin reuptake inhibitor (SSRI) that works on preventing breakdown of the neurotransmitters serotonin and norepinephrine while increasing levels of the neurotransmitters at same time. The active ingredient, sertraline hydrochloride, belongs to the class of drugs known as atypical neuroleptics and is the most commonly prescribed antidepressant. Sertraline is the only SSRI medication licensed in the U.S. that is approved by the U.S. Food and Drug Administration (FDA) for the treatment of depression. Sertraline is available to healthcare providers, who use it to treat depression and other mood disorders, for an average annual cost of $6,800. More Information You can learn more about the side effects of sertraline, including changes in Priligy on prescription libido, sleep, appetite and body weight as you age, from the FDA's Medication Guide and online at www.fda.gov/medwatch or call the FDA at 1-866-447-8848. More information about Sertraline with Depression is available at http://www.sertraline.com/depression/basics.html. References Nemeth SM, Fava CM, Susskind L. Sertraline is effective in relieving the depression associated with chronic fatigue syndrome. J Clin Psychiatry 2008; 68;631-634. Tart J et al. The effectiveness of sertraline for treatment chronic fatigue syndrome: a placebo-controlled controlled trial. J Clin Psychiatry 2007; 63;541-548. Levy D et al. A meta-analysis of antidepressants in treatment-resistant depression. Am J Psychiatry 2017; 202:1-11.

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